论著摘要 |【AI-CT】用于新发展骨转移的前列腺癌患者的骨闪烁显像术的计算机辅助诊断系统的诊断性能:为了寻找低敏感性亚组(双语版)

2018-01-18 11:28:26 admin 0
标签:  AI 人工神经网络 CT 骨转移 前列腺癌

Diagnostic performance of a computer-assisted diagnosis system for bone scintigraphy of newly developed skeletal metastasis in prostate cancer patients: search for low-sensitivity subgroups.

发表日期: 2017.04.29   来源:Ann Nucl Med. 2017 Aug;31(7):521-528.

作者:

Kazuki Motegi1, Masamichi Koyama1, Takashi Terauchi1, Takeshi Yuasa2 , Junji Yonese2.

作者介绍:

1. Department of Nuclear Medicine, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

2. Department of Urology, Cancer Institute Hospital, Tokyo, Japan.

摘要

Abstact

目的

在骨闪烁显像术中使用计算机辅助诊断系统(BS)BONENAVI来评估骨转移。我们研究了其在有和无骨转移的前列腺癌患者中的诊断性能,并寻找问题。

Purpose

The computer-assisted diagnostic system for bone scintigraphy (BS) BONENAVI is used to evaluate skeletal metastasis. We investigated its diagnostic performance in prostate cancer patients with and without skeletal metastasis and searched for the problems.

方法

使用BS计算226名前列腺癌患者(124名患有骨转移,101名患者没有)的人工神经网络(ANN)值。 进行接受者操作特征曲线分析并且确定灵敏度和特异性(截止ANN = 0.5)。 分析诊断骨转移时的病人情况,计算机断层扫描(CT)类型,疾病程度(EOD)和BS摄取等级。记录假阴性和假阳性结果。

Methods

An artificial neural network (ANN) value was calculated in 226 prostate cancer patients (124 with skeletal metastasis and 101 without) using BS. Receiver operating characteristic curve analysis was performed and the sensitivity and specificity determined (cutoff ANN = 0.5). Patient's situation at the time of diagnosis of skeletal metastasis, computed tomography (CT) type, extent of disease (EOD), and BS uptake grade were analyzed. False-negative and false-positive results were recorded.

结果

BONENAVI显示转移检测的灵敏度为82%(102/124),特异性为83%(84/101)。尽管低EOD和微弱的BS摄取与低的ANN值和低的灵敏度相关,但CT类型之间没有显著差异。随访期间患者的敏感性低于前期诊断检查。假阴性病变常位于骨盆或邻近骨盆。它们不仅包括孤立的,微弱的BS病变,还压迫尿排泄。

Results

BONENAVI showed 82% (102/124) of sensitivity and 83% (84/101) specificity for metastasis detection. There were no significant differences among CT types, although low EOD and faint BS uptake were associated with low ANN values and low sensitivity. Patients showed lower sensitivity during the follow-up period than staging work-up. False-negative lesions were often located in the pelvis or adjacent to it. They comprised not only solitary, faint BS lesions but also overlaying to urinary excretion.

结论

BONENAVI与BS对检测前列腺癌的骨转移具有良好的敏感性和特异性。 低EOD和微弱的BS摄取与低敏感度相关,但与CT类型不相关。在随访期间可能有假阴性结果的前列腺癌患者在盆腔内有孤立病变,微弱的BS摄取或病灶压迫尿排泄。

Conclusions

BONENAVI with BS has good sensitivity and specificity for detecting prostate cancer's osseous metastasis. Low EOD and faint BS uptake are associated with low sensitivity but not the CT type. Prostate cancer patients likely to have false-negative results during the follow-up period had a solitary lesion in the pelvis with faint BS uptake or lesions overlaying to urinary excretion.

关键词:

骨转移;骨闪烁显像;计算机辅助诊断;前列腺癌

Keywords:

Bone metastasis; Bone scintigraphy; Computer-assisted diagnosis; Prostate cancer

阅读原文:PMID: 28456877  PMCID: PMC5517559  DOI: 10.1007/s12149-017-1175-2


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